1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands

Methvin B Isaac; Tao Xin; Anne O'Brien; David St-Martin; Angela Naismith; Neil MacLean; Julie Wilson; Lidia Demchyshyn; Ashok Tehim; Abdelmalik Slassi

doi:10.1016/s0960-894x(02)00438-9

1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2451-4. doi: 10.1016/s0960-894x(02)00438-9.

Authors

Methvin B Isaac¹, Tao Xin, Anne O'Brien, David St-Martin, Angela Naismith, Neil MacLean, Julie Wilson, Lidia Demchyshyn, Ashok Tehim, Abdelmalik Slassi

Affiliation

¹ NPS Pharmaceuticals Inc., Mississauga, ON, Canada. misaac@npsp.com

PMID: 12161155
DOI: 10.1016/s0960-894x(02)00438-9

Abstract

A novel series of 1-(bicyclopiperazinyl)ethylindole and 1-(homopiperazinyl)ethyl-indole derivatives was synthesized and found to be potent and selective 5-HT(7) receptor ligands.

MeSH terms

Humans
Indoles / chemical synthesis*
Indoles / pharmacology
Ligands
Protein Binding
Receptors, Serotonin / drug effects*
Serotonin Antagonists / chemical synthesis*
Serotonin Antagonists / pharmacology
Structure-Activity Relationship

Substances

Indoles
Ligands
Receptors, Serotonin
Serotonin Antagonists
serotonin 7 receptor